Cardiac autonomic neuropathy in nonobese young adults with type 1 diabetes

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Cardiac Autonomic Neuropathy in Diabetes

CASE PRESENTATION — A 26year-old woman with “brittle” type 1 diabetes and severe CAN experienced sudden cardiac death. She had a 16-year history of poor diabetes control presenting with wide blood glucose fluctuations, recurrent episodes of severe hypoglycemia, and hypoglycemia unawareness. Over time she developed persistent orthostatic hypotension with daily falls in systolic blood pressure ra...

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Cardiac autonomic neuropathy and early progressive renal decline in patients with nonmacroalbuminuric type 1 diabetes.

BACKGROUND AND OBJECTIVES Cardiac autonomic neuropathy predicts future adverse renal outcomes in the general population. This study sought to determine its relationship with early progressive renal decline in type 1 diabetes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A subset of participants with normoalbuminuria (n=204) or microalbuminuria (n=166) from the First Joslin Kidney Study under...

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Clinical predictors of cardiac autonomic neuropathy in patients with type 1 diabetes

Results CAN was diagnosed in 39 (38.2%) patients. No statistically significant differences were found in age (34.87±9.71 vs. 33.90±11.74 yrs.; p=0.467), age at diagnosis (15.10±9.16 vs. 17.38±11.29 yrs.; p=0.495) and HbA1c (9.26%±2.04 vs. 8.84%±2.07; p=0.144) between groups. Hypertension and dyslipidemia were seen more frequently in patients with CAN (61.5 vs. 19%; p≤0.001 and 51.3 vs. 22.2%; p...

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Diabetic Autonomic Neuropathy and Circadian Misalignment in Type 1 Diabetes

Misalignment of circadian rhythms has been evidenced in patients with type 1 diabetes and there is a close relationship between alterations in neuroendocrine sleep architecture, circa‐ dian clock oscillations, glucose metabolism, autonomic function, and diurnal profiles of blood pressure and heart rate [1-5]. In turn, circadian misalignment may modify the peak incidence of cardiovascular events...

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Cardiovascular Autonomic Neuropathy Contributes to Sleep Apnea in Young and Lean Type 1 Diabetes Mellitus Patients

Knowledge about association between sleep apnea and cardiovascular autonomic neuropathy (CAN) in type 1 diabetes mellitus (T1DM) might give some insight into the pathogenesis of this condition in these patients. In obese patients, excessive central adiposity, including a large neck circumference, can contribute to obstructive sleep apnea (OSA). Its presence in non-obese patients, however, indic...

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ژورنال

عنوان ژورنال: Annals of Pediatric Endocrinology & Metabolism

سال: 2019

ISSN: 2287-1012,2287-1292

DOI: 10.6065/apem.2019.24.3.180